• Tue. Mar 28th, 2023

NASA Spaceline Present Consciousness Record #1,041 17 March 2023 (Area Life Science Analysis Outcomes)


Mar 18, 2023

SPACELINE Present Consciousness Lists are distributed by way of listserv and can be found on the NASA Process Ebook web site at https://taskbook.nasaprs.com/Publication/spaceline.cfm

Please ship any correspondence to Shawna Byrd, SPACELINE Present Consciousness Senior Editor, [email protected].

Name for articles to quote within the weekly lists: Authors at NASA Facilities and NASA PIs—do you might have an article that has lately revealed or will publish within the upcoming weeks inside a peer-reviewed journal and is within the scope of area life sciences? If that’s the case, ship it our manner! Ship your article to the e-mail tackle talked about above. Articles acquired by Wednesday will seem inside that week’s record—articles acquired after Wednesday will seem the next week.

Papers deriving from NASA help:


Freeborn TJ, Critcher S, Hooper G.

Segmental tissue resistance of wholesome younger adults throughout 4 hours of 6-degree head-down-tilt positioning.

Sensors (Basel). 2023 Mar 3;23(5):2793.


Notice: Head-down tilt examine. This text could also be obtained on-line with out cost.

Journal Impression Issue: 3.847

Funding: “This analysis was supported by funding from the Alabama NASA EPSCoR FY19 Analysis Infrastructure Improvement, grant 80NSSC19M0051.”


Lawrence LM, Wage RR, Miller V, Valluri A, Denning KL, Case-Perry S, Abdelgaber Ok, Smith S, Claudio PP, Day JB.Osteoregenerative potential of 3D-printed poly ε-caprolactone tissue scaffolds in vitro utilizing minimally manipulative growth of main human bone marrow stem cells.

Int J Mol Sci. 2023 Mar 3;24(5):4940.


Notice: This text could also be obtained on-line with out cost.

Journal Impression Issue: 6.208

Funding: “The current research have been partially funded by a Marshall College translational analysis award (to P.P.C.) As well as, this analysis work was partially funded by the NASA Established Program to Stimulate Aggressive Analysis (EPSCoR)—Speedy Response Analysis, Grant #80NSSC22M0249 (to R.S.).”


Flatt AJ, Peleckis AJ, Dalton-Bakes C, Nguyen HL, Ilany S, Matus A, Malone SK, Goel N, Jang S, Weimer J, Lee I, Rickels MR.

Automated insulin supply for hypoglycemia avoidance and glucose counterregulation in long-standing sort 1 diabetes with hypoglycemia unawareness.

Diabetes Technol Ther. 2023 Feb 24. On-line forward of print.


PI: N. Goel

Journal Impression Issue: 7.337

Funding: “This work was supported by Public Well being Service analysis grants R01 DK091331 (to M.R.R.), UL1 TR001878 (College of Pennsylvania Middle for Human Phenomic Science), P30 DK19525 (College of Pennsylvania Diabetes Analysis Middle), K99NR017416 (to S.Ok.M.), and R01 DK11788 (to N.G.); Nationwide Aeronautics and Area Administration (NASA) grants NNX14AN49G and 80NSSC20K0243 (to N.G.); Pennsylvania Division of Well being grant SAP 4100079750 (to I.L.); the Charles B. Humpton, Jr. Endowed Fellowship in Diabetes Analysis (to A.J.F.); and the Human Metabolism Useful resource of the College of Pennsylvania Institute for Diabetes, Weight problems & Metabolism. Medtronic provided discounted 670G insulin pumps and glucose monitoring units for the examine by means of investigator-initiated grant NERP16-015 (to M.R.R.).”


Mogul R, Miller DR, Ramos B, Lalla SJ.

Metabolomic and cultivation insights into the tolerance of the spacecraft-associated Acinetobacter towards Kleenol 30, a cleanroom ground detergent.

Entrance Microbiol. 2023 Mar 6;14:1090740.


Notice: This text is a part of Analysis Subject “The Impression of the Area Setting on Microbial Development and Habits” (https://www.frontiersin.org/research-topics/27130/the-impact-of-the-space-environment-on-microbial-growth-and-behavior#overview). The Analysis Subject additionally contains articles from earlier Present Consciousness Record #1,009 https://doi.org/10.3389/fmicb.2022.877625, https://doi.org/10.3389/fmicb.2022.893071, and https://doi.org/10.3389/fmicb.2022.909997. Further articles will probably be forthcoming and could also be discovered within the hyperlink to the Analysis Subject. This text could also be obtained on-line with out cost.

Journal Impression Issue: 6.064

Funding: “This work was supported by a grant (NNH18ZDA001N) from the Planetary Safety Analysis element of the Nationwide Aeronautics and Area Administration (NASA) Analysis Alternatives in Area and Earth Sciences program.”


Tyson TL, Flynn-Evans EE, Stone LS.

Differential saccade-pursuit coordination underneath sleep loss and low-dose alcohol.

Entrance Neurosci. 2023 Feb 16;16:1067722.


Notice: This text appeared in final week’s Present Consciousness record and it’s showing once more to incorporate the write-up of the article from writer L.S. Stone: “This examine demonstrates that eye-movement-based efficiency metrics (oculometrics) are delicate sufficient to detect small deficits and particular sufficient to tell apart potential causes. Particularly, low-dose alcohol (< 0.05% BAC) ends in impairment of the cortically managed pursuit system whereas sleep loss (24 hours awake) impacts cortical, midbrain, and brainstem areas that management each pursuit and the saccadic backup system. Oculometrics additionally confirmed that caffeine largely mitigates pursuit deficits from sleep loss however doesn’t restore regular saccades. These findings validate the potential use of oculometrics for the detection/analysis of gentle neural impairment in operational settings and the evaluation of countermeasure efficacy.” This text could also be obtained on-line with out cost.

Journal Impression Issue: 5.152

Funding: “This analysis was supported by the Workplace of Naval Analysis (ONR), NASA’s Human Analysis Program (HRP), and Ames Middle Innovation Fund (CIF).”


Different papers of curiosity:


Kuldavletova O, Navarro Morales DC, Quarck G, Denise P, Clément G.

Spaceflight alters response time and period judgment of astronauts.

Entrance Physiol. 2023 Mar 17;14:1141078.


Notice: ISS outcomes. This text is a part of Analysis Subject “Brains in Area: Results of Spaceflight on the Human Mind and Habits-Quantity II” (https://www.frontiersin.org/research-topics/47491/brains-in-space-effects-of-spaceflight-on-the-human-brain-and-behavior—volume-ii#overview). Further articles will probably be forthcoming and could also be discovered within the hyperlink to the Analysis Subject. This text could also be obtained on-line with out cost.


Capri M, Conte M, Ciurca E, Pirazzini C, Garagnani P, Santoro A, Longo F, Salvioli S, Lau P, Moeller R, Jordan J, Illig T, Villanueva MM, Gruber M, Bürkle A, Franceschi C, Rittweger J.

Lengthy-term human spaceflight and inflammaging: Does it promote growing older?

Ageing Res Rev. 2023 Mar 12;101909. Evaluation.


Notice: From the summary: “Spaceflight and its related stressors, similar to microgravity, radiation publicity, confinement, circadian derailment, and disruptive workloads symbolize an unprecedented sort of exposome that’s totally novel from an evolutionary stand level. Inside this attitude, we aimed to evaluation the consequences of extended spaceflight on immune-neuroendocrine techniques, mind and brain-gut axis, cardiovascular system and musculoskeletal equipment, highlighting particularly the similarities with an accelerated growing older course of.”


Ghosh D, Verma E, Gershman S, Anderson T, Kumar Ghosh R, Peter M.

Central nervous system throughout human spaceflight missions to Mars. A meta-analysis.

Int J Med Sci Clin Invent. 2023 Jan 15;10(01):6411-50.

Notice: From the summary: “The outcomes of greater than 50 years of space-related neuroscience research on folks and animals subjected to spaceflight or settings which might be just like spaceflight are reviewed on this article, together with their implications and the longer term work wanted to make sure profitable Mars missions.” This text could also be obtained on-line with out cost.


Ghosh D, Verma E, Kumar Ghosh R, Gershman S, Anderson T, Peter M.

Challenges and alternatives for neuroscience within the context of spaceflight and the central nervous system.

Int J Med Sci Clin Invent. 2023 Jan 15;10(01):6397-410.

Notice: From the article: “We give a abstract of what’s presently identified concerning the influence of microgravity on the central nervous system (CNS), each in human and mobile fashions, primarily based on precise spaceflight and parabolic flight investigations in addition to ground-based strategies acceptable for microgravity-based analysis. Moreover, we examine the influence of microgravity on the biology of tumor cells on this evaluation, concentrating on mind tumor cells, as a way to present a recent perspective on the examine of most cancers and considerably novel therapeutic approaches.” This text could also be obtained on-line with out cost.


Marfia G, Guarnaccia L, Navone SE, Ampollini A, Balsamo M, Benelli F, Gaudino C, Garzia E, Fratocchi C, Di Murro C, Ligarotti GK, Campanella C, Landolfi A, Perelli P, Locatelli M, Ciniglio Appiani G.

Microgravity and the intervertebral disc: The influence of area situations on the biomechanics of the backbone.

Entrance Physiol. 2023 Mar 14;14:1124991. Evaluation.


Notice: From the article: “Within the current work, the mechanisms of disc degeneration, the situations of microgravity, and their affiliation have been mentioned as a way to determine potential molecular mechanisms underlying disc degeneration and the associated medical manifestations as a way to develop a mannequin of prevention to take care of well being and efficiency of air- and space-travelers. The give attention to microgravity additionally permits the event of recent proofs of idea with potential therapeutic implications.” This text could also be obtained on-line with out cost.


Thoolen SJJ, Kuypers M.

Exterior hemorrhage management methods for human area exploration: Classes from the battlefield.

Wilderness Environ Med. 2023 Mar 9. Evaluation. On-line forward of print.



Aventaggiato M, Barreca F, Vitiello L, Vespa S, Valente S, Rotili D, Mai A, Lotti LV, Sansone L, Russo MA, Bizzarri M, Ferretti E, Tafani M.

Position of SIRT3 in microgravity response: A brand new participant in muscle tissue restoration.

Cells. 2023 Feb 22;12(5):691.


Notice: A rotary cell tradition system was used on this examine. This text and the article under (Dubayle et al.) are a part of Particular Problem “New Insights into Microgravity and Area Biology” (https://www.mdpi.com/journal/cells/special_issues/R75D12X7FZ). The Particular Problem additionally contains articles from earlier Present Consciousness Lists #1,028 https://doi.org/10.3390/cells11233871and #1,032 https://doi.org/10.3390/cells12020246. Further articles will probably be forthcoming and could also be discovered within the hyperlink to the Particular Problem. This text could also be obtained on-line with out cost.


Dubayle D, Vanden-Bossche A, Peixoto T, Morel JL.

Hypergravity will increase blood-brain barrier permeability to fluorescent dextran and antisense oligonucleotide in mice.

Cells. 2023 Feb 24;12(5).


Notice: This text and the article above (Aventaggiato et al.) are a part of Particular Problem “New Insights into Microgravity and Area Biology” (https://www.mdpi.com/journal/cells/special_issues/R75D12X7FZ). This text could also be obtained on-line with out cost.


Cui Y, Liu W, Zhao S, Zhao Y, Dai J.

Advances in microgravity directed tissue engineering.

Adv Healthc Mater. 2023 Mar 9;e2202768. Evaluation. On-line forward of print.


Notice: From the summary: “Right here, the present standing, current advances, challenges, and prospects of microgravity associated to tissue engineering are reviewed.”


Ismaeel A, Van Pelt DW, Hettinger ZR, Fu X, Richards CI, Butterfield TA, Petrocelli JJ, Vechetti IJ, Confides AL, Drummond MJ, Dupont-Versteegden EE.

Extracellular vesicle distribution and localization in skeletal muscle at relaxation and following disuse atrophy.

Skelet Muscle. 2023 Mar 10;13:6.


Notice: Hindlimb unloading examine.


Vilchinskaya N, Lim WF, Belova S, Roberts TC, Wooden MJA, Lomonosova Y.

Investigating eEF2k/eEF2 pathway regulation and its function in protein synthesis impairment throughout disuse-induced skeletal muscle atrophy.

Am J Pathol. 2023 Mar 3;S0002-9440(23)00060-3. On-line forward of print.



Wang Y, Liu H, Wei H, Wu C, Yuan F.

The impact of a knee brace on muscle forces throughout single-leg landings at two heights.

Int J Environ Res Public Well being. 2023 Mar 6;20(5):4652.


Notice: From the summary: “Single-leg touchdown is without doubt one of the maneuvers that has been linked to non-contact anterior cruciate ligament (ACL) accidents, and sporting knee braces has been proven to cut back ACL damage incidence. The aim of this examine was to find out whether or not sporting a knee brace has an impact on muscle pressure throughout single-leg landings at two heights by means of musculoskeletal simulation.” This text could also be obtained on-line with out cost.


Liu CJ, Yang X, Wang SH, Wu XT, Mao Y, Shi JW, Fan YB, Solar LW.

Stopping disused bone loss by means of inhibition of superior glycation finish merchandise.

Int J Mol Sci. 2023 Mar 3;24(5):4953.


Notice: This text is a part of Part “Biochemistry” (https://www.mdpi.com/journal/ijms/sections/biochemistry) and could also be obtained on-line with out cost.


Guez-Barber D, Colon LM, Raphael D, Wragan MA, Yun S, Eisch AJ.

Feminine and male microglia usually are not completely different within the dentate gyrus of postnatal day 10 mice.

Neuroscience Letters. 2023 Mar 8;137171.


Notice: From the summary: “Microglia, the resident immune cells of the mind, help regular mind operate and the mind’s response to illness and damage. The hippocampal dentate gyrus (DG) is an space of microglial examine attributable to its central function in lots of behavioral and cognitive features. Curiously, microglia and associated cells are distinct in feminine vs. male rodents, even in youth. Certainly, postnatal day (P)-dependent intercourse variations in quantity, density, and morphology of microglia have been reported in sure hippocampal subregions at particular ages. Nevertheless, intercourse variations within the DG haven’t but been assessed at P10, a rodent developmental time level translationally related to human time period gestation. To deal with this data hole, Iba1+ cells within the DG (that are enriched within the Hilus and Molecular Layer) in feminine and male C57BL/6J mice have been analyzed for his or her quantity (by way of stereology) and density (by way of stereology and by way of sampling).”


Cariati I, Bonanni R, Rinaldi AM, Marini M, Iundusi R, Gasbarra E, Tancredi V, Tarantino U.

Recombinant irisin prevents cell dying and mineralization defects induced by random positioning machine publicity in main cultures of human osteoblasts: A promising technique for the osteoporosis therapy.

Entrance Physiol. 2023 Mar 15;14:1107933.


Notice: A random positioning machine was used on this examine.


Ge YX, Zhuang HJ, Zhang TW, Liang HF, Ding W, Zhou L, Dong ZR, Hu ZC, Chen Q, Dong J, Jiang LB, Yin XF.

Exact manipulation of circadian clock utilizing MnO2

 nanocapsules to amplify photodynamic remedy for osteosarcoma.

Mater At this time Bio. 2023 Apr;19:100547.



Zhang P, Yan J, Liu Z, Zhou Q.

Impeded frontal-occipital communications throughout Go/Nogo duties in people owing to psychological workload.

Behav Mind Res. 2023 Feb 13;438:114182.


Notice: From the summary: “Human brains depend on oscillatory coupling mechanisms for regulating entry to prefrontal cognitive sources, dynamically speaking between the frontal and distant cortex. We fear that communications throughout cortical areas will probably be impeded when people in excessive area environments journey with psychological load work, affecting the profitable completion of missions. Right here, we monitored crews of staff performing a Go/Nogo activity in area journey, accompanied by acquisitions of electroencephalography (EEG) indicators.”


Cavelli ML, Mao R, Findlay G, Driessen Ok, Bugnon T, Tononi G, Cirelli C.

Sleep/wake adjustments in perturbational complexity in rats and mice.

iScience. 2023 Mar 17;26(3):106186.


Notice: From the summary: “In people, the extent of consciousness is assessed by quantifying the spatiotemporal complexity of cortical responses utilizing Perturbational Complexity Index (PCI) and associated PCIst

 (st, state transitions). Right here, we validate PCIst

 in freely transferring rats and mice by exhibiting that it’s decrease in NREM sleep and gradual wave anesthesia than in wake or REM sleep, as in people.” This text could also be obtained on-line with out cost.

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