Supporting FivepHusion’s International Growth and Commercialization Technique

SYDNEY, Might 26, 2023 /PRNewswire/ — FivepHusion, a complicated clinical-stage biotechnology firm, as we speak introduced its collaboration with Treehill Companions, a New York-based strategic and monetary advisory agency specializing in healthcare trade transactions, and Syneos Well being® (Nasdaq: SYNH), a number one absolutely built-in biopharmaceutical options group, to develop and produce a novel, enhanced chemotherapeutic product to market.

Treehill Companions will assist FivepHusion with built-in enterprise growth, operational, strategic and transactional experience. Syneos Well being will assist FivepHusion’s built-in medical growth and commercialization capabilities. This collaboration is designed to strategically and optimally progress growth and commercialization of FivepHusion’s enhanced chemotherapeutic formulation Deflexifol™ in international markets.

“It is a very thrilling time for FivepHusion. We’re at a vital stage in our development technique. By collaborating with Treehill Companions and Syneos Well being, we consider we’re positioned to efficiently carry our growth work on Deflexifol™ to international markets, together with within the US, Europe and Asia,” stated Dr. Christian Toouli, CEO & Managing Director, FivepHusion. “This collaboration represents a novel working mannequin to the trade. By the mixed energy and competency of three trade leaders, we intend to maximise our progress on the event of Deflexifol™ and shortly carry progressive oncology medicines to sufferers in want.”

“We’re excited to collaborate with FivepHusion and Treehill Companions to assist carry Deflexifol™ to sufferers,” stated Christian Tucat, Chief Enterprise Officer, Syneos Well being. “Leveraging our deep therapeutic and international experience, Syneos Well being is happy to contribute to accelerating the medical growth and commercialization of this necessary new remedy.”

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“This collaboration represents a brand new mannequin of built-in providers throughout disciplines, designed to permit US and non-US rising gamers to play a key function on the worldwide stage, and we’re proud to work alongside FivepHusion and Syneos Well being,” stated Ali Pashazadeh, Accomplice & Co-founder, Treehill Companions. “By merging the scientific prowess of our purchasers with the medical and industrial experience of Syneos Well being and Treehill’s healthcare advisory and execution capabilities, we’re offering a novel ecosystem designed to assist firms to flourish regardless of the present difficult market atmosphere.”

About FivepHusion

FivepHusion (www.fivephusion.com) is a complicated clinical-stage, globally targeted biotechnology firm whose function is to optimize chemotherapy to enhance affected person remedy outcomes and high quality of life.

FivepHusion is creating Deflexifol™, a proprietary, novel, and optimized physiological pH formulation to co-administer the chemotherapeutic agent 5-fluorouracil (5-FU) and its biomodulator leucovorin (LV), a drug that enhances 5-FU anti-cancer exercise. These medication are generally used globally to deal with varied strong tumors together with colorectal, pancreatic, gastric and breast cancers. Nonetheless, as a result of their chemical incompatibility, present formulations of 5-FU and LV undergo from limitations of their security, tolerability, effectiveness and pharmacological compatibility. These disadvantages contribute to restricted remedy response charges, disagreeable negative effects and toxicities, and a diminished high quality of life skilled by most cancers sufferers. Deflexifol™ has been designed to handle these limitations by co-administration of the 2 brokers with clinically demonstrated enhancements in security and tolerability and the potential to supply superior anti-tumor efficacy, higher high quality of life, and general enhanced medical profit for most cancers sufferers.

FivepHusion is creating Deflexifol™ by way of the FDA 505(b)(2) and EMA Article 10b regulatory pathways as a bioequivalent, chemotherapy alternative of sub-optimal commonplace of care formulations of 5-FU and LV for the remedy of metastatic colorectal most cancers, and different tumors with a projected international incidence of larger than 6 million sufferers. Deflexifol™ can also be being developed as a brand new remedy for cancers with excessive unmet medical want, together with pediatric ependymoma; a uncommon and lethal mind most cancers which afflicts very younger youngsters.

Deflexifol™ is a trademark of FivepHusion.

About Syneos Well being

Syneos Well being® (Nasdaq: SYNH) is a number one absolutely built-in biopharmaceutical options group constructed to speed up buyer success.  Syneos interprets distinctive medical, medical affairs and industrial insights into outcomes to handle fashionable market realities.

Syneos brings collectively a gifted workforce of pros, who work throughout greater than 110 nations, with a deep understanding of affected person and doctor behaviors and market dynamics. Collectively Syneos shares insights, makes use of the newest applied sciences and applies superior enterprise practices to hurry clients’ supply of necessary therapies to sufferers.

Syneos Well being helps a various, equitable and inclusive tradition that cares for colleagues, clients, sufferers, communities and the atmosphere.

To study extra about how Syneos are Shortening the space from lab to life®, go to syneoshealth.com or subscribe to our podcast.

About Treehill Companions

Treehill was based in 2014 and is led by accomplice and co-founder Ali Pashazadeh, who beforehand headed Blackstone’s healthcare advisory workforce and UBS’ European biotech protection.

Treehill helps purchasers within the healthcare trade all through the asset lifecycle, from buy-side acquisition and funding over worth construct and development to sell-side disposal and divestment. Key areas of focus are the figuring out and executing of worth artistic transactions and their knitting into profitable company evolution methods.

In delivering its recommendation, the agency employs a multidisciplinary senior workforce with impeccable pedigree that contains medical medical doctors/ MDs, scientists/ PhDs, CEOs of biotechs, senior executives from giant pharma, and skilled technique consultants and funding bankers. Providers supplied are centered across the “principal mentality” of the workforce, delivering actionable strategic and transaction recommendation that issues to CEOs, senior management, their stakeholders and buyers.

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SOURCE FivepHusion