Intriguing research from a team of scientists backed by the U.S. National Science Foundation has shed light on the remarkable adaptations of ocean creatures to diverse environments, which could have profound implications for understanding the human brain. Researchers from multiple disciplines employed tools from the NSF-funded Center for High-Energy X-ray Sciences at the Cornell High Energy Synchrotron Source to study deep-sea and shallow-water comb jellies. Their findings revealed that these creatures have evolved by developing differently shaped lipid molecules in their cell membranes, enabling them to maintain optimal stability based on their habitat.
Intriguingly, deep-sea comb jellies brought to the surface experience membrane breakdown due to the lack of external pressure, causing them to “melt.” On the other hand, shallow-water jellies struggle to function at deep-sea pressure levels due to the rigidity of their membranes. These discoveries not only enhance our comprehension of survival mechanisms in extreme environments but also offer potential insights into human biology and neurodegenerative diseases such as Alzheimer’s.
The researchers found that plasmalogens, lipids abundant in deep-sea comb jellies’ membranes, are also prevalent in human brains. Loss of plasmalogens has been linked to disease progression and aging in humans. The researchers believe that their findings about plasmalogen structure could provide valuable insights into how these molecules function in human physiology and disease processes. Overall, this fascinating research provides a unique perspective on how organisms can adapt to challenging environments and could lead to new avenues for understanding complex biological systems like the human brain.
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