Creating a six-legged mouse for the first time

Beyond Genitals: Portuguese Scientists Create Extra Legged Mice with Tgfbr1 Mutations

In Portugal, a team of scientists has successfully created a 6-legged mouse embryo with an extra pair of hind legs instead of external genitalia. Moisés Mallo, a biologist at the Gulbenkian Institute of Sciences in Oerias, Portugal, and his colleagues have been studying a receptor protein called Tgfbr1, which plays a crucial role in embryonic development.

The Tgfbr1 gene codes for a protein called transforming growth factor beta type 1 receptor, which is involved in cellular responses like cell growth and division. Mutations in this gene can increase the risk of skin cancer. The researchers discovered that inactivating the Tgfbr1 gene in mouse embryos led to the development of hind legs instead of external genitalia.

Tgfbr1 dictates whether structures develop into genitals or legs. This means that by altering the activity of other genes, mice with extra legs and no external genitalia can be produced. The research team plans to investigate how Tgfbr1 and related genes affect other systems such as cancer metastasis and whether similar processes occur in reptiles with double penises.

The embryos used in the study were collected from mice aged 3-6 months, and the research team dissected them without distinguishing between male and female embryos since their external genitalia do not differ significantly. Further research will focus on understanding the broader implications of the Tgfbr1 gene in development and disease.

Overall, this groundbreaking study provides new insights into how genes regulate embryonic development and could pave the way for future research on regenerative medicine and genetic engineering.

Leave a Reply

Is reforming the regulation of the right to strike in transport an impossible task? Previous post Strikes in Public Transport and the Importance of Choosing the Right Flooring for Your Home
Blinken’s Call with Aliyev Highlights Escalating Tensions at the Border Next post Peace Process in Nagorno-Karabakh: Azerbaijan, Armenia, and Diplomatic Efforts